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  • Title: Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization.
    Author: Perni RB, Pitlik J, Britt SD, Court JJ, Courtney LF, Deininger DD, Farmer LJ, Gates CA, Harbeson SL, Levin RB, Lin C, Lin K, Moon YC, Luong YP, O'Malley ET, Rao BG, Thomson JA, Tung RD, Van Drie JH, Wei Y.
    Journal: Bioorg Med Chem Lett; 2004 Mar 22; 14(6):1441-6. PubMed ID: 15006379.
    Abstract:
    The alpha-ketoamide warhead (e.g., 15) was found to be a practical replacement for aliphatic aldehydes in a series of HCV NS3.4A protease inhibitors. Structure-activity relationships and prime side optimization are discussed.
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