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  • Title: [Effects of olprinone hydrochloride after coronary artery bypass grafting].
    Author: Arai T.
    Journal: Masui; 2004 Feb; 53(2):122-30. PubMed ID: 15011418.
    Abstract:
    BACKGROUND: We have examined the effect of olprinone hydrochloride on hemodynamics and peripheral circulation after cardiopulmonary bypass (CPB) in 56 patients who underwent coronary artery bypass grfting. METHODS: The subjects were randomly classified into 2 groups: B-group of 25 patients who received bolus plus continuous administration of olprinone hydrochloride and control group without administration of olprinone hydrochloride (C-group) of 31 patients. In the B-group, after de-clamping of the aortic occlusion, olprinone hydrochloride 15 micrograms.kg-1 bolus was administered and followed by continuous administration at 0.1 microgram.kg-1.min-1. RESULTS: We excluded six cases in C-group in whom it was not possible to maintain blood pressure without olprinone hydrochloride. In the B-group, peripheral temperature was kept significantly higher and blood lactic acid value was kept significantly lower until 6 hours after the operation compared with C-group. In the B-group, cardiac index was kept significantly higher for a long period of time, and dosage of concomitantly used catecholamine could be significantly reduced. CONCLUSIONS: Olprinone increased CI and decreased SVRI, and it led to easy weaning from CPB, providing excellent hemodynamics after CABG. These results suggest that olprinone hydrochloride 15 micrograms.kg-1 bolus plus 0.1 microgram.kg-1.min-1 continuous administration may be effective for improvement of hemodynamics and peripheral circulation after CPB.
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