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  • Title: Simultaneous occurrence of perimembranous glomerulonephritis and glomerular amyloidosis.
    Author: Bohle A, Fischbach H, Gärtner HV, von Gise H, Helmchen U, Potjan K, Wildhirt E.
    Journal: Virchows Arch A Pathol Anat Histol; 1978 Jul 26; 378(4):315-20. PubMed ID: 150118.
    Abstract:
    The results of electron microscopic examination of renal biopsies from 3 patients with rheumatoid arthritis treated with penicillamine are presented. All 3 patients developed a nephrotic syndrome upon discontinuation of penicillamine therapy. When viewed with the electron microscope, segmental forms of perimembranous glomerulonephritis (Stages I-II of Ehrenreich and Churg) and glomerular renal amyloidosis Grade I-III were observed. In all three cases the nephrotic syndrome was considered to be due to the simultaneous occurrence of the two disease processes. In 2 cases perimembranous glomerulonephritis with immuno-complex-deposits was assumed to be the dominant factor in the causation of the disease, in the other case amyloidosis was the principle abnormality.
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