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  • Title: Early recurrence of hepatocellular carcinoma after living donor liver transplantation.
    Author: Ohkubo T, Sugawara Y, Imamura H, Kaneko J, Matsui Y, Makuuchi M.
    Journal: Hepatogastroenterology; 2004; 51(55):237-8. PubMed ID: 15011872.
    Abstract:
    Milan criteria are standards for considering the indications of liver transplantation for hepatocellular carcinoma. A 57-year-old man underwent living donor liver transplantation for hepatitis B-related liver cirrhosis and hepatocellular carcinoma. Hepatocellular carcinoma had been treated with percutaneous microwave coagulation therapy and transarterial chemoembolization. Resected specimens revealed a solitary necrotic tumor 5 cm in diameter, which satisfied the Milan criteria. Although the patient survived the operation, he suffered from tumor recurrence in the graft and lung 2 months afterward. Adjuvant chemotherapy had no effect and the patient expired 7 months after transplantation. The present results indicate that a tumor satisfying the Milan criteria does not necessarily guarantee long-term survival after transplantation.
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