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  • Title: Synthesis of 3-iodoindoles by electrophilic cyclization of N,N-dialkyl-2-(1-alkynyl)anilines.
    Author: Yue D, Larock RC.
    Journal: Org Lett; 2004 Mar 18; 6(6):1037-40. PubMed ID: 15012094.
    Abstract:
    [reaction: see text] A wide variety of N-alkyl-3-iodoindoles are readily prepared under very mild reaction conditions by the palladium/copper-catalyzed cross-coupling of N,N-dialkyl-o-iodoanilines and terminal alkynes, followed by electrophilic cyclization by I(2)(). Alkyl-, aryl-, and vinylic-substituted alkynes all undergo iodocyclization in excellent yields.
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