These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates.
    Author: Zloh M, Kaatz GW, Gibbons S.
    Journal: Bioorg Med Chem Lett; 2004 Feb 23; 14(4):881-5. PubMed ID: 15012986.
    Abstract:
    Multidrug-resistance (MDR) occurs in many bacterial species and tumour cells. MDR functions by membrane proteins which export drugs from cells, resulting in a low ineffective concentration of the drug. We have shown by molecular modelling that inhibitors of MDR have affinity for substrates of MDR transporters. This affinity may facilitate drug entry into cells and a large inhibitor-drug complex may be a poorer substrate for the MDR mechanism. This complex would effectively 'cloak' the drug rendering it unavailable for efflux.
    [Abstract] [Full Text] [Related] [New Search]