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  • Title: Synthesis of angiogenesis-targeted peptide and hydrophobized polyethylene glycol conjugate.
    Author: Maeda N, Takeuchi Y, Takada M, Namba Y, Oku N.
    Journal: Bioorg Med Chem Lett; 2004 Feb 23; 14(4):1015-7. PubMed ID: 15013013.
    Abstract:
    For the purpose of cancer antineovascular therapy, a novel angiogenesis-targeted peptide, Ala-Pro-Arg-Pro-Gly, (APRPG) was attached to hydrophobized polyethylene glycol (distearoylphosphatidylethanolamine [DSPE]-PEG). DSPE-PEG and the 5-mer peptide were condensed with DCC-HOBt method. Liposome modified with this DSPE-PEG-APRPG conjugate highly accumulated in tumor of tumor-bearing mice.
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