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  • Title: Bull's-eye maculopathy associated with quinacrine therapy for malaria.
    Author: Browning DJ.
    Journal: Am J Ophthalmol; 2004 Mar; 137(3):577-9. PubMed ID: 15013892.
    Abstract:
    PURPOSE: To report a side effect of quinacrine therapy for malaria. DESIGN: Case report. METHODS: Review of clinical chart and photographs. SETTING: Private retina practice. RESULTS: A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria. Progression of the clinical picture was documented over 15 years of follow-up. The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy. CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.
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