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  • Title: [Effects of realgar on tissue factor expression of NB4 and MR2 cells].
    Author: Zhao XA, Liu SX.
    Journal: Zhongguo Zhong Yao Za Zhi; 2003 Jun; 28(6):553-6. PubMed ID: 15015339.
    Abstract:
    OBJECTIVE: To investigate the effects of Realgar on procoagulant activity (PCA), tissue factor expression and tissue factor mRNA transcription in acute promyelocytic leukemia (APL) cell lines NB4 and MR2 cells. METHOD: NB4 and MR2 cells were treated with 300 micrograms.L-1 Realgar PCA of the treated cells was detected using one-stage clotting assay. TF antigen was detected by ELISA and TFmRNA by semi-quantitive RT-PCR. RESULT: The PCA and TF antigen level in NB4 and MR2 cells were significantly higher than that in HL-60 and K562 cells. Realgar could down-regulate the membrane PCA, TF antigen and TF mRNA transcription of NB4 and MR2 cells in a time-dependent manner. CONCLUSION: Down-regulating TF expression and PCA of NB4 and MR2 cells by Realgar may be one of the mechanism of its improvement effect on DIC-related hemorrhage of APL patients.
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