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  • Title: [Effects of yixintong on regulating cellular calcium channels].
    Author: Li SC, Huang H, Zheng FM, Wen DL, Mo SW.
    Journal: Zhongguo Zhong Yao Za Zhi; 2003 Aug; 28(8):754-6. PubMed ID: 15015360.
    Abstract:
    OBJECTIVE: To explore the protecting mechanism of Yixintong for heart ischemia-reperfusion injury at cellular and subcellular levels, by observing the effects of Yixintong on three kinds of calcium channels. METHOD: The effects of Yixintong on Ca2+ influx on leak calcium channel, receptor-operationg calcium channel (ROC) and pulse-dependent calcium channel (PDC) were observed respectively, by using rat aortic smooth muscle cell and radioactive 45Ca technique. RESULT: Yixintong has no effects on leak calcium channel, but can inhibit the Ca2+ influx in ROC and PDC significantly. CONCLUSION: Yixintong can inhibit the Ca2+ influx in slow channel in a dose-dependent manner.
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