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  • Title: Expression of interleukin-21 and -23 in human esophageal tumors produced antitumor effects in nude mice.
    Author: Shan B, Yu L, Shimozato O, Li Q, Tagawa M.
    Journal: Anticancer Res; 2004; 24(1):79-82. PubMed ID: 15015579.
    Abstract:
    Interleukin (IL)-21 induces proliferation of activated T and natural killer (NK) cells and enhances the lytic function of NK cells. IL-23, a heterodimer composed of p19 and p40 molecule, can also enhance T cell proliferation and interferon-gamma production from activated T cells; however, its effects on NK cells are currently unknown. We therefore examined whether human tumors expressing IL-21 or IL-23 could produce antitumor effects in inoculated nude mice. Esophageal tumor T.Tn cells were retrovirally transduced with the IL-21 gene (T.Tn/IL-21) or the p19-linked p40 genes (T.Tn/IL-23). The proliferation in vitro and the class I expression of the major histocompatibility complexes of these transduced cells were not different from those of parent cells. T.Tn/IL-21 and T.Tn/IL-23 cells developed small tumors in nude mice, but the tumors regressed spontaneously thereafter in contrast to parent tumors. Expressed IL-21 or IL-23 in human esophageal tumors can produce antitumor effects in a T cell-defective condition.
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