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  • Title: Circulating endothelin-3 levels in patients with sickle cell disease during hydroxyurea treatment.
    Author: Makis AC, Hatzimichael EC, Kolios G, Bourantas KL.
    Journal: Haematologica; 2004 Mar; 89(3):360-1. PubMed ID: 15020278.
    Abstract:
    Abnormal adhesion of red blood cells to the endothelium and the production of cytokines and vasoactive substances, such as endothelin-1 contribute to the pathogenesis of microvascular occlusion in sickle cell disease (SCD), even during the steady state. Endothelin-3 (ET-3) is a vasoconstrictive agent, which has not yet been studied in SCD.
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