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  • Title: C-reactive proteins as an indicator of sub-clinical infection in cases of premature rupture of membranes.
    Author: Saini S, Goel N, Sharma M, Arora B, Garg N.
    Journal: Indian J Pathol Microbiol; 2003 Jul; 46(3):515-6. PubMed ID: 15025328.
    Abstract:
    The present study was conducted on 25 cases of preterm, premature rupture of membranes and 25 patients preterm with intact membranes, between 28-36 weeks of gestation, admitted in the maternity ward of Obstetrics and Gynecology, PGIMS, Rohtak. The sensitivity and specificity of CRP determination was found to be 80% each as an early predictor of subclinical chorioamnionitis. TLC had a low sensitivity of 20% and specificity of 60% in detecting histopathological chorioamnionitis. So CRP estimation is a reliable marker for detection of early choriamnionitis, at the same time, it is quite affordable and reasonably simple.
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