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  • Title: De novo synthesis of oligosaccharides using a palladium-catalyzed glycosylation reaction.
    Author: Babu RS, Zhou M, O'Doherty GA.
    Journal: J Am Chem Soc; 2004 Mar 24; 126(11):3428-9. PubMed ID: 15025462.
    Abstract:
    The natural all d- and/or unnatural all l-1,4- and 1,6-oligosaccharides were synthesized from furan alcohols using a palladium-catalyzed glycosylation reaction. The 1,4- and 1,6-alpha-manno-disaccharides were achieved in seven total steps starting from chiral furan alcohols. Similarly, 1,4- and 1,6-alpha-manno-trisaccharides were also synthesized in nine total steps. Key to the overall efficiency of this process was the use of highly diastereoselective palladium-catalyzed glycosylations, reductions, and dihydroxylations.
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