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  • Title: Confocal microscopy evaluation of stromal ablation depth after myopic laser in situ keratomileusis and photorefractive keratectomy.
    Author: Erie JC, Hodge DO, Bourne WM.
    Journal: J Cataract Refract Surg; 2004 Feb; 30(2):321-5. PubMed ID: 15030819.
    Abstract:
    PURPOSE: To compare the measured ablation depth after myopic laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) with the predicted ablation depth. SETTING: Mayo Clinic, Rochester, Minnesota, USA. METHODS: Twenty-five eyes of 15 patients had PRK and 25 eyes of 15 patients had LASIK to correct refractive errors between -1.50 diopters (D) and -11.00 D. The corneas were examined by in vivo confocal microscopy before and 1 month after both procedures. Thickness measurements were obtained from digital-image analysis of confocal scans. The measured ablation depth, an estimate of the actual photoablation depth, was obtained as the surgically induced stromal thinning between the preoperative and the 1-month post-PRK or post-LASIK central stromal thickness. The predicted ablation depth was recorded from the laser's software program. RESULTS: In LASIK, the measured ablation depth (81 microm +/- 34 [SD]) was 25% greater than the predicted ablation depth (65 +/- 13 microm, P =.007) and the difference between the measured and predicted ablation depths was positively associated with the mean ablation depth (r = 0.81, P<.001). In PRK, there was no difference between the measured ablation depth (48 +/- 19 microm) and the predicted ablation depth (47 +/- 18 microm, P =.84). CONCLUSION: Significantly more tissue than predicted was removed by LASIK than by PRK excimer photoablation with the laser system used in this study.
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