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  • Title: High erythrocyte membrane (Na+ + K+)-ATPase in kwashiorkor, in vivo reversal by diuretic.
    Author: Kaplay SS, Ramanadham M.
    Journal: Clin Chim Acta; 1978 Aug 15; 88(1):89-92. PubMed ID: 150319.
    Abstract:
    Specific activity (mumol Pi released/h/mg membrane protein) of ouabain-sensitive (Na+ + K+)-ATPase has been shown to be higher in erythrocytes from children suffering from kwashiorkor, compared to that in normal children. Twenty four hours after treatment of these children with a diuretic, there was reduction in their body weights due to loss of oedema fluid. Ouabain sensitive (Na+ + K+)-ATPase of the erythrocyte membrane was inhibited by about 40% and this was associated with gain of 1.8 mequivalents Na+ per litre of erythrocytes. The results suggest that high ouabain-sensitive (Na+ + K+)-ATPase could be one of the mechanisms operative in erythrocytes to prevent accumulation of Na+ in kwashiorkor.
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