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  • Title: [Intraarterial chemotherapy with bladder preservation in patients with invasive bladder carcinoma].
    Author: Shiba M, Takatera H, Fujii T, Tokizane T, Shimizu K, Tushima J.
    Journal: Hinyokika Kiyo; 2004 Jan; 50(1):15-9. PubMed ID: 15032009.
    Abstract:
    Intraarterial chemotherapy (IAC) was carried out on patients with invasive bladder carcinoma to treat the bladder carcinoma while preserving the bladder. Fifteen patients with bladder carcinoma at stage T2-T4 were treated with intraarterial cisplatin (CDDP: 70 mg/m2) and adriamycin (ADM: 30 mg/m2) every 3 to 4 weeks. The response was observed in all 15 patients. Ten (66.7%) achieved a complete response (CR), and 3 (20.0%) obtained a partial response (PR). With a mean follow-up of 22.6 months, the overall survival rate was 86.7% and 12 patients were alive with functioning bladder. One patient received radical cystectomy. Although further studies and long-term follow up are required to clarify its effectiveness, IAC for patients with invasive bladder carcinoma might be an effective therapy with a preserved bladder.
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