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  • Title: Antimicrobial activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines.
    Author: Motohashi N, Sakagami H, Kurihara T, Ferenczy L, Csuri K, Molnar J.
    Journal: Anticancer Res; 1992; 12(4):1207-10. PubMed ID: 1503410.
    Abstract:
    The abilities of 14 phenothiazines, 8 benzo[a]phenothiazines and 12 benz[c]acridines to induce an antibacterial effect against Escherichia coli K12 were compared. Several phenothiazines, which showed antiplasmid activity, displayed the most potent antibacterial activity. All benz[c]acridine derivatives were moderately antibacterial, whereas benzo[a]phenothiazines were inactive. The active phenothiazine derivatives had more potent inhibitory activity against fungi, including phytopathogen filamentous, human pathogen filamentous fungi and yeasts, than against gram-positive and -negative bacteria. Taken together with previously reported data, the induction mechanism of antimicrobial and antiplasmid activity by these compounds seems to be different from that of antitumor, differentiation-inducing and carcinogenic activity.
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