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  • Title: Modulation of neurotransmission by reciprocal synapse-glial interactions at the neuromuscular junction.
    Author: Auld DS, Colomar A, Bélair EL, Castonguay A, Pinard A, Rousse I, Thomas S, Robitaille R.
    Journal: J Neurocytol; 2003; 32(5-8):1003-15. PubMed ID: 15034282.
    Abstract:
    Perisynaptic Schwann cells are glial cells that are closely associated with pre- and postsynaptic elements of the neuromuscular junction. Recent evidence shows that these cells detect and modulate neurotransmission in an activity-dependent fashion. Through G-protein signalling and Ca(2+) released from internal stores they can decrease or increase neurotransmitter release, respectively. Thus, they help to establish the level of neurotransmission associated with activity dependent short-term synaptic plasticity. We discuss evidence implicating perisynaptic Schwann cells as being active partners in neurotransmission at the neuromuscular junction, with emphasis on the modulation of short-term plasticity and potential implications for long-term changes.
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