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  • Title: Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci.
    Author: Arthur M, Molinas C, Bugg TD, Wright GD, Walsh CT, Courvalin P.
    Journal: Antimicrob Agents Chemother; 1992 Apr; 36(4):867-9. PubMed ID: 1503450.
    Abstract:
    The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore appears to be a substrate of VanA in vivo.
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