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  • Title: Multiple binge alcohol consumption during rat adolescence increases anxiety but does not impair retention in the passive avoidance task.
    Author: Popović M, Caballero-Bleda M, Puelles L, Guerri C.
    Journal: Neurosci Lett; 2004 Mar 04; 357(2):79-82. PubMed ID: 15036579.
    Abstract:
    We investigated the effect of binge alcohol consumption on anxiety-related behavior and memory in adolescent male Wistar rats. Three consecutive daily sessions of ethanol administration (5 g/kg) were repeated weekly for 4 weeks. The retention of passive avoidance was measured weekly, 48 h following the treatment. Three days after the last memory test a novel object exploration test was done. There was no significant difference in step-through latency between the groups, but the ethanol-treated group displayed a significantly higher incidence of defecation, and an increased number of boluses during the passive avoidance test. The latency to explore a novel object was also higher, while the duration of exploration was significantly lower. Together, these data suggest that binge alcohol consumption in adolescent rats does not impair their memory in passive avoidance tasks, but may significantly increase their anxiety.
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