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  • Title: Expression of astrocytic nestin in the rat hippocampus during trimethyltin-induced neurodegeneration.
    Author: Geloso MC, Corvino V, Cavallo V, Toesca A, Guadagni E, Passalacqua R, Michetti F.
    Journal: Neurosci Lett; 2004 Mar 04; 357(2):103-6. PubMed ID: 15036585.
    Abstract:
    In this study we used an immunocytochemical approach to study nestin expression in the rat hippocampus during trimethyltin-induced neurodegeneration at different time points (5, 10, 15, 21 and 50 days) after intoxication. Nestin is transiently expressed by a subpopulation of astroglial cells strictly associated with pyramidal neurons in those hippocampal areas severely affected by degeneration. This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation.
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