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  • Title: Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi.
    Author: Park HJ, Seong YM, Choi JY, Kang S, Rhim H.
    Journal: Neurosci Lett; 2004 Feb 26; 357(1):63-7. PubMed ID: 15036614.
    Abstract:
    Amyloid beta (Abeta), a principle component of the cerebral plaques found in the brains of patients with Alzheimer's disease (AD), is a pivotal factor implicated in the pathogenesis of AD. Recent reports show that not only extracellular Abeta but also intracellular Abeta induces neuronal apoptosis; however, the mechanism remains to be elucidated. Using yeast two-hybrid assays, we found that Abeta interacts with HtrA2/Omi, an essential human serine protease with proapoptotic activity. Additionally, we mapped the C-terminal region containing the PDZ domain of HtrA2/Omi as the binding determinant for Abeta? The interaction of Abeta with HtrA2/Omi was further confirmed through in vivo co-immunoprecipitation assay in HEK293 cells. This study suggests the possibility that the accumulation of intracellular Abeta and a function of proapoptotic protease, HtrA2/Omi are correlated.
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