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  • Title: [Clinical activity and serum immunoglobulin concentrations in patients with ankylosing spondylitis].
    Author: Casals Sánchez JL, González Calvin J, García Sánchez A, Abellán Pérez M, Salvatierra Ríos D.
    Journal: An Med Interna; 1992 May; 9(5):214-6. PubMed ID: 1504201.
    Abstract:
    Several authors have suggested that immunoglobulin A plays a pathogenic role in ankylosing spondylitis. We have determined the levels of immunoglobulins in 30 patients, observing higher levels than in control patients (248 vs 176 mg/dl); p less than 0.01) and a relation between the increase of immunoglobulin A and the presence of clinical activity in the subgroup of patients B27-negative (163 vs 398 mg/dl, p less than 0.005), but not in B27-positive patients. We think that these e results support the hypothesis that ankylosing spondylitis is an heterogeneous disease, with different pathogenic mechanisms depending on the presence or absence of the serological marker HLA-B27.
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