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  • Title: Novel caprolactones from a marine streptomycete.
    Author: Stritzke K, Schulz S, Laatsch H, Helmke E, Beil W.
    Journal: J Nat Prod; 2004 Mar; 67(3):395-401. PubMed ID: 15043417.
    Abstract:
    Two new caprolactones, (R)-10-methyl-6-undecanolide (1) and (6R,10S)-10-methyl-6-dodecanolide (2), were identified in the lipid extract of a marine streptomycete (isolate B6007). Their structures were proposed on the basis of GC-MS experiments and proved by synthesis. The absolute configuration of the compounds was established by comparison of the natural and synthetic stereoisomers using chiral gas chromatography. These caprolactones show a moderate phytotoxicity and a promising activity against cancer cells with concomitant low general cytotoxicity.
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