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  • Title: New cytotoxic steroids from the Indian Ocean sponge Axinella cf. bidderi.
    Author: Funel C, Berrué F, Roussakis C, Fernandez Rodriguez R, Amade P.
    Journal: J Nat Prod; 2004 Mar; 67(3):491-4. PubMed ID: 15043442.
    Abstract:
    Four new sterols have been isolated from the marine sponge Axinella cf. bidderi, 17alpha-hydroxy-22,23-epoxy-24-methylcholest-5-en-3beta-ol (1) and 17alpha-hydroxy-22,23-epoxycholest-5-en-3beta-ol (2), together with 3 and 4, which possess respectively the cholestene and the cholestane skeleton with a cyclic enol ether linkage between C-18 and C-22. The structures were elucidated using spectroscopic data. The in vitro activity was evaluated against prostate, ovary, pancreas, colon, and lung cell lines.
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