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  • Title: The nitration of tau protein in neurone-like PC12 cells.
    Author: Cappelletti G, Tedeschi G, Maggioni MG, Negri A, Nonnis S, Maci R.
    Journal: FEBS Lett; 2004 Mar 26; 562(1-3):35-9. PubMed ID: 15043998.
    Abstract:
    Tyrosine nitration of proteins is emerging as a post-translational modification playing a role in physiological conditions. Looking for the molecular events triggered by nitric oxide in nerve growth factor-induced neuronal differentiation, we now find that nitration occurs on the microtubule-associated protein tau. In differentiated PC12 cells, we have identified as tau a nitrated protein that co-immunoprecipitates with alpha-tubulin and indicated that the modified protein is associated with the cytoskeleton but it is confined to a restricted cell region. This paper supplies the first evidence that nitration of tau occurs in a physiological process and suggests that it could play a role in neuronal differentiation.
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