These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of glucocorticoids on 3-nitropropionic acid-induced oxidative stress in synaptosomes.
    Author: Montilla P, Túnez I, Muñoz MC, Salcedo M, Feijóo M, Muñoz-Castañeda JR, Bujalance I.
    Journal: Eur J Pharmacol; 2004 Mar 19; 488(1-3):19-25. PubMed ID: 15044031.
    Abstract:
    The present study with rat striatal and cortical synaptosomes evaluated the effect of dexamethasone (300 microg/kg i.p./day) with and without simultaneous adrenalectomy on the oxidative stress induced by 3-nitropropionic acid (20 mg/kg/day for 4 days). Adrenalectomy enhanced the oxidative stress induced by 3-nitropropionic acid. These changes were prevented by previous and simultaneous administration of dexamethasone. Adrenalectomy alone induced oxidative stress with decreases in succinate dehydrogenase activity. Our results revealed that adrenal glucocorticoids, and especially dexamethasone (synthetic glucocorticoid), have a protective effect against oxidative stress induced by 3-nitropropionic acid in some brain regions of the Wistar rat.
    [Abstract] [Full Text] [Related] [New Search]