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  • Title: Rapid induction of atherosclerosis in rabbits.
    Author: Saso Y, Kitamura K, Yasoshima A, Iwasaki HO, Takashima K, Doi K, Morita T.
    Journal: Histol Histopathol; 1992 Jul; 7(3):315-20. PubMed ID: 1504449.
    Abstract:
    Japanese white rabbits fed a restricted amount (100 g/head/day) of an atherogenic diet (AD) containing 0.2% cholesterol and 6% peanut oil showed mild and persistent hypercholesterolemia (338 +/- 79 mg/dl). They developed atherosclerotic lesions 4 weeks after deendothelialization of aorta carried out at the 4th week of AD-feeding. This rabbit model of atherosclerosis has such advantages as being able to be produced in a short period and having similar biochemical and pathological characteristics with those in human atherosclerosis.
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