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  • Title: PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency.
    Author: Naoki K, Asano K, Satoh N, Fukunaga K, Oguma T, Shiomi T, Suzuki Y, Nakajima T, Niimi K, Shiraishi Y, Ishizaka A, Yamaguchi K.
    Journal: Biochem Biophys Res Commun; 2004 Apr 23; 317(1):205-10. PubMed ID: 15047169.
    Abstract:
    Approximately 4% of the Japanese population genetically lack plasma platelet activating factor acetylhydrolase (PAF-AH) and show a higher prevalence of thromboembolic disease, but whether they are susceptible to another PAF-related disease, asthma, remains controversial. To determine the role of plasma PAF-AH in airway physiology, we performed PAF bronchoprovocation tests in 8 plasma PAF-AH-deficient subjects and 16 control subjects. Serial inhalation of PAF (1-1000 microg/ml) concentration-dependently induced acute bronchoconstriction, but there was no significant difference between PAF-AH-deficient and control subjects (11.7 +/- 4.6% vs. 9.6 +/- 2.8% decrease in forced expiratory volume in 1 s). Transient neutropenia after single inhalation of PAF (1000 microg/ml) showed no significant difference between the groups either in its magnitude (72 +/- 11% vs. 65 +/- 9% decrease) or duration (4.1 +/- 1.0 vs. 3.3 +/- 0.8 min). In conclusion, a lack of plasma PAF-AH activity alone does not augment physiological responses to PAF in the airway.
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