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  • Title: 6,7-dihydroxyflavone dramatically intensifies the susceptibility of methicillin-resistant or -sensitive Staphylococcus aureus to beta-lactams.
    Author: Sato Y, Shibata H, Arakaki N, Higuti T.
    Journal: Antimicrob Agents Chemother; 2004 Apr; 48(4):1357-60. PubMed ID: 15047543.
    Abstract:
    We have demonstrated that 6,7-dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA) but that at concentrations less than MIC it synergistically elevates the susceptibility of clinically isolated MRSA and methicillin-sensitive S. aureus strains to beta-lactam antibiotics from 8- to 32,800-fold.
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