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  • Title: Characterization of collagen-like heterotrimers: implications for triple-helix stability.
    Author: Berisio R, Granata V, Vitagliano L, Zagari A.
    Journal: Biopolymers; 2004 Apr 15; 73(6):682-8. PubMed ID: 15048771.
    Abstract:
    This article deals with the effects of proline hydroxylation on collagen triple-helix stability, an issue that is still under discussion. To investigate the structural determinants of triple-helix stabilization by hydroxyproline (Hyp), we here characterized spectroscopically triple-helix heterotrimers containing both chains of (Pro-Pro-Gly)10 and (Pro-Hyp-Gly)10. Results are discussed in relation to the various triple-helix stabilization mechanisms.
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