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  • Title: Nisin production by Lactococcus lactis subsp. lactis under nutritional limitation in fed-batch culture.
    Author: Lv W, Cong W, Cai Z.
    Journal: Biotechnol Lett; 2004 Feb; 26(3):235-8. PubMed ID: 15049369.
    Abstract:
    Nisin production was improved under nutritional limitation in fed-batch culture of Lactococcus lactis. Nisin titre reached 3887 IU ml(-1) by a slow feeding of sucrose and 4131 IU ml(-1) by slow feeding of nitrogen source, which were, respectively, 64% and 74% above the values in batch culture.
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