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  • Title: Anticonvulsant activity of Schiff bases of isatin derivatives.
    Author: Verma M, Pandeya SN, Singh KN, Stables JP.
    Journal: Acta Pharm; 2004 Mar; 54(1):49-56. PubMed ID: 15050044.
    Abstract:
    Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin (2) exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs phenytoin, carbamazepine and valproic acid. Thus, compound 2 may be chosen as a prototype for development of new anticonvulsants.
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