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  • Title: Loracarbef (LY 163892) vs amoxicillin/clavulanate in bacterial maxillary sinusitis.
    Author: Sydnor TA, Scheld WM, Gwaltney J, Nielsen RW, Huck W, Therasse DG.
    Journal: Ear Nose Throat J; 1992 May; 71(5):225-32. PubMed ID: 1505371.
    Abstract:
    Loracarbef (LY 163892), a beta-lactam antibiotic (carbacephem), was compared with amoxicillin/clavulanate potassium in a 10-day, single-blind, randomized parallel trial in the treatment of acute bacterial maxillary sinusitis. Based on posttherapy aspirate and culture, there was a 95.2% bacteriologic cure rate in patients receiving loracarbef (400 mg twice daily) and an 86.7% cure rate in patients receiving amoxicillin/clavulanate (500/125 mg three times daily) (p = 0.359). Loracarbef was comparable in efficacy to amoxicillin/clavulanate with a more desirable safety profile.
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