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  • Title: c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat.
    Author: Strömberg I, Hansson AC, Rimondini R, Sommer W.
    Journal: Brain Res; 2004 Mar 12; 1000(1-2):192-4. PubMed ID: 15053967.
    Abstract:
    Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.
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