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  • Title: Dynamic combinatorial carbohydrate libraries: probing the binding site of the concanavalin A lectin.
    Author: Ramström O, Lohmann S, Bunyapaiboonsri T, Lehn JM.
    Journal: Chemistry; 2004 Apr 02; 10(7):1711-5. PubMed ID: 15054758.
    Abstract:
    Dynamic combinatorial chemistry (DCC) has emerged as an efficient approach to receptor/ligand identification based on the generation of combinatorial libraries by reversible interconversion of the library constituents. In this study, the implementation of such libraries on carbohydrate-lectin interactions was examined with the plant lectin Concanavalin A as a target species. Dynamic carbohydrate libraries were generated from a pool of carbohydrate aldehydes and hydrazide linker/scaffold components through reversible acylhydrazone exchange, resulting in libraries containing up to 474 constituents. Dynamic deconvolution allowed the efficient identification of the structural features required for binding to Concanavalin A and the selection of a strong binder, a tritopic mannoside, showing an IC(50)-value of 22 microM.
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