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  • Title: Surfactant protein A in the course of respiratory distress syndrome.
    Author: Stevens PA, Schadow B, Bartholain S, Segerer H, Obladen M.
    Journal: Eur J Pediatr; 1992 Aug; 151(8):596-600. PubMed ID: 1505580.
    Abstract:
    Surfactant-associated protein (SP-A) was measured in tracheal aspirates of ventilated infants with (n = 51) and without (n = 21) respiratory distress syndrome (RDS). SP-A concentrations in samples collected after birth were significantly lower in RDS than in infants ventilated for other reasons than RDS (median 0.03 vs. 1.60 micrograms/ml). As a biochemical test to diagnose RDS early after birth, the sensitivity of measuring SP-A in tracheal aspirates was 87% and specificity 81%. SP-A content in tracheal aspirates of infants with RDS was monitored during the first 7 days of life. A significant (P less than 0.001) increase within the first 4 days was found in those infants who survived, whereas no such change was found in those infants who died.
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