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  • Title: Pigmented mammary Paget's disease mimicking melanoma.
    Author: Pizzichetta MA, Canzonieri V, Massarut S, Gloghini A, Trevisan G, Veronesi A, Soyer HP.
    Journal: Melanoma Res; 2004 Apr; 14(2):S13-5. PubMed ID: 15057051.
    Abstract:
    Our case of pigmented mammary Paget's disease simulated melanoma clinically and dermoscopically. Histologically, the lesion was characterized by microscopic features similar to those seen in malignant melanoma and, to a lesser extent, in Bowen's disease (intra-epidermal squamous cell carcinoma). Immunohistochemical studies demonstrated that the tumor cells were positive for keratins (Cam 5.2+MNF 116) and AE1-AE3 and negative for HMB-45 and S-100 proteins. In conclusion clinical and dermoscopic examination cannot reliably distinguish melanoma from epithelial pre-neoplastic or neoplastic disease, therefore the differentiation of pigmented Paget's disease from superficial spreading of melanoma and Bowen's disease is based on histopathologic integrated with immunohistochemical criteria.
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