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  • Title: [The influence of adrenalectomy on the treatment of arterial hypertension in patients with benign adrenal medullary and cortical tumors].
    Author: Ziaja JM, Cierpka LD, Król RJ, Gasińska TE, Tuszyński GJ, Cholewa KW, Kajor MW.
    Journal: Wiad Lek; 2003; 56(11-12):545-51. PubMed ID: 15058162.
    Abstract:
    One of the reasons of secondary arterial hypertension (HA) are pathological lesions of adrenal glands. The aim of the study was to estimate the influence of performed adrenalectomy on the values of arterial blood pressure (RR) in patients with adrenal tumours and HA observed at least one year after surgical treatment. Data of 54 patients were analysed. Hormonal activity of adrenal tumours was diagnosed in 57.4% of patients. 83.3% of patients underwent unilateral and 16.7% bilateral adrenalectomy. Pathological examination revealed the presence of pheochromocytoma in 14.8% of patients, adenoma in 59.3% and hyperplasia in 25.9%. The observation time was 43.0 +/- 21.3 months from the operation. The mean maximal value of SBP measured during the time of observation was significantly lower than observed before surgery and amounted to 152.4 +/- 27.0 mm Hg and DBP 96.6 +/- 17.7 mm Hg. The decrease of maximal value of SBP amounted to 52.7 +/- 40.9 mm Hg and DBP 26.8 +/- 24.8 mm Hg. In 87.0% of patients performed surgery caused that symptoms of the disease accompanying HA regressed or decreased, and in 72.2% allowed to reduce the number and doses of antihypertensive drugs. Surgical excision of adrenal tumours in patients with pheochromocytoma as well as with Conn and Cushing syndrome leads to significant reduction of maximal RR values. In patients without confirmation of hormone activity of the tumour qualification to the surgical treatment should be based on clinical symptoms accompanying HA as well as on the size of the tumour.
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