These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Experimental research on total flavone from Elsholtzia blanda against xiongbi symptom].
    Author: Lou H, He Q, Wu H, Lou Y.
    Journal: Zhong Yao Cai; 2003 Dec; 26(12):878-80. PubMed ID: 15058209.
    Abstract:
    OBJECTIVE: To study the protective effect and mechanism of total flavone from Elsholtzia blanda (TFEB) on Xiongbi symptom induced by coronary artery ligation in rats. METHODS: The left anterior descending coronary artery (LAD) of male rat was ligated for 3 h after feeding TFEB or 0.5% CMC for 5 d by ig. Then, the rats were decollated and the left ventricle were dyed by nitrotetrazolum blue chloride(NBT) to distinguish infraction area from non-infraction area. Myocardial infarction index was calculated accordingly to assess the effect of TFEB on myocardial ischemia. A piece of ventricular muscle come from apex of heart was dyed by hematoxylin and eosin (HE) to observe the degree of myocardial lesions by microscopic examination. Nitric oxide (NO) level in serum was measured to demonstrate the relevant mechanism. RESULTS: TFEB could markedly reduce the myocardial infraction index in a dose-dependent fashion (P < 0.05-0.01). Microscopic examination showed that the myocardium of sham group had no lesion in morphology and the muscle fiber kept integrity and the cardiac myocyte lined up in order. While control group displayed extensive swelling, rupture, confluent, even break in cardiac myocyte. TFEB could relieve the lesion degree of myocardium. NO level in serum after LAD ligation in TFEB 100 and 150 mg/kg groups was markedly reduced(P < 0.05-0.01). CONCLUSION: TFEB has protective effect on myocardial ischemia induced by LAD ligation in rats and can prevent against Xiongbi symptom, possibly via the decrease of NO level in serum.
    [Abstract] [Full Text] [Related] [New Search]