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  • Title: Demyelination during anti-tumor necrosis factor alpha therapy with infliximab for Crohn's disease.
    Author: Thomas CW, Weinshenker BG, Sandborn WJ.
    Journal: Inflamm Bowel Dis; 2004 Jan; 10(1):28-31. PubMed ID: 15058523.
    Abstract:
    BACKGROUND: Inflammatory demyelinating disease of the central nervous system may be linked to anti-tumor necrosis factor alpha therapy. CASE HISTORY: A 19-year-old female with Crohn's ileocolitis developed right arm and leg numbness and right hand weakness 4 weeks after the initiation of infliximab. Neurologic examination confirmed upper and lower right extremity sensory and motor deficits. MRI examination of the head and thoracic cord showed multiple gadolinium-enhancing lesions with distribution and configuration most suggestive of multiple sclerosis or other demyelinating process. The infliximab therapy was immediately stopped and follow-up at 8 weeks revealed symptomatic improvement. CONCLUSION: This case report describes the onset of a demyelinating process after the institution of infliximab therapy in a patient with Crohn's disease.
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