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  • Title: TIP: protein backtranslation aided by genetic algorithms.
    Author: Moreira A, Maass A.
    Journal: Bioinformatics; 2004 Sep 01; 20(13):2148-9. PubMed ID: 15059829.
    Abstract:
    UNLABELLED: Several applications require the backtranslation of a protein sequence into a nucleic acid sequence. The degeneracy of the genetic code makes this process ambiguous; moreover, not every translation is equally viable. The usual answer is to mimic the codon usage of the target species; however, this does not capture all the relevant features of the 'genomic styles' from different taxa. The program TIP ' Traducción Inversa de Proteínas') applies genetic algorithms to improve the backtranslation, by minimizing the difference of some coding statistics with respect to their average value in the target. AVAILABILITY: http://www.cmm.uchile.cl/genoma/tip/
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