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  • Title: Tuberculosis-like lesions arising from the use of Freund's complete adjuvant in an owl monkey (Aotus sp.).
    Author: Málaga CA, Weller RE, Roger Broderson J, Gozalo AS.
    Journal: J Med Primatol; 2004 Apr; 33(2):109-12. PubMed ID: 15061724.
    Abstract:
    An apparently normal, non-tuberculin-reacting, splenectomized owl monkey presented tuberculosis-like lesions of the lung at necropsy. Histological and bacteriological examination failed to demonstrate the presence of acid-fast organisms. Retrospective inquiry showed the animal had been inoculated using complete Freund's adjuvant during a malaria vaccine trial. Lesions observed were compatible with lipid embolism of the adjuvant in the lungs.
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