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  • Title: [Curling and kinking of hair caused by etretinate].
    Author: Schauder S, Tsambaos D, Nikiforidis G.
    Journal: Hautarzt; 1992 Aug; 43(8):509-13. PubMed ID: 1506218.
    Abstract:
    In two female psoriasis patients, curling and kinking of the scalp hair developed subsequent to a long-term etretinate therapy. Scanning electron microscopic examination of kinking hair revealed twists with sharp-edged defects and splitting of the cuticle cells in several hairshafts. The quantitative determination of the mechanical parameters of these hairs using a computerized system revealed statistically significant changes from the pattern in the scalp hair of untreated psoriasis patients. This finding suggests etretinate-induced alteration of the expression of the psoriatic phenotype in the keratin composition of hair in psoriasis patients.
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