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  • Title: Changes of plasma proteins after immunoadsorption using Ig-Adsopak columns in patients with myasthenia gravis.
    Author: Pták J.
    Journal: Transfus Apher Sci; 2004 Apr; 30(2):125-9. PubMed ID: 15062750.
    Abstract:
    BACKGROUND AND OBJECTIVES: Ig-Adsopak immunoadsorption columns were used for treatment to determine their influence on the amount of immunoglobulins and other plasma proteins. PATIENTS AND METHODS: Patients with myasthenia gravis were treated, 178 immunoadsorption procedures were performed. The mean plasma volume treated in a 2-4 week interval was 3600 ml. Plasma protein concentrations were measured prior to and after each treatment. The concentration of anti-acetylcholine receptor antibodies was also measured. RESULTS: The amounts of the IgG, IgM and IgA removed were respectively, 55.7%, 42.8% and 43.4% of the initial level whereas the other plasma proteins were found to bind with a lower affinity with only 19.8% removal. 60.9% of the anti-acetylcholine receptor antibodies were removed. CONCLUSIONS: Ig-Adsopak columns have a semi-specific effect on the plasma proteins, mostly on immunoglobulins of all classes.
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