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  • Title: Fructose-1,6-diphosphatase deficiency: a rare cause of prolonged prothrombin time.
    Author: Nitzan O, Saliba WR, Goldstein LH, Elias MS.
    Journal: Ann Hematol; 2004 May; 83(5):302-3. PubMed ID: 15064857.
    Abstract:
    A 20-year-old woman presented with severe life-threatening metabolic acidosis and hypoglycemia. In addition, her blood tests revealed elevated hepatic enzymes and a prolonged prothrombin time, with a reduction in factor VII activity. After treatment with a glucose and bicarbonate-containing intravenous infusion, there was a dramatic clinical improvement and normalization of the prothrombin time within 2 days. The patient was found to have fructose-1,6-diphosphatase deficiency, a rare metabolic disorder which has not been described previously as causing coagulation defects.
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