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  • Title: [Effect of rat liver chalones on liver cell proliferation at different times after partial hepatectomy].
    Author: Chekulaeva LI, Ketlinskiĭ SA, Okulov VB.
    Journal: Tsitologiia; 1978 Apr; 20(4):436-40. PubMed ID: 150667.
    Abstract:
    The action of rat's liver ethanol extract (72--81 per cent saturation) on cell proliferation of this organ at various periods after a partial hepatectomy has been studied. The most sensitive periods of the action of G1- and G2-chalone were, resp., the time of cell transformation, and the middle of the premitotic period of cell cycle. The action of G2-chalone used is organ-specific, since the drug decreased the mitotic activity of both hepatocytes and stromal cells. At the same time, the proliferation of ear, tongue and small bowel epithelial cells remained unchanged.
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