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  • Title: Dietary fat regulates mammary stearoyl coA desaturase expression and activity in lactating mice.
    Author: Singh K, Hartley DG, McFadden TB, Mackenzie DD.
    Journal: J Dairy Res; 2004 Feb; 71(1):1-6. PubMed ID: 15068059.
    Abstract:
    Mice in mid lactation (n=6 per group) were fed a control diet (1.19% fat), or diets containing safflower oil (25% w/w) or olive oil (25% w/w) for 7d. Mammary and liver stearoyl CoA desaturase (SCD) mRNA levels and mammary SCD activities were higher in lactating mice fed the control diet than in those fed the oil-supplemented diets. Further, mammary SCD mRNA was directly related to mammary SCD activity. Milk fat composition was influenced by dietary fat composition. The olive oil diet, high in 18:1, led to high levels of this fatty acid in milk and the safflower oil diet, high in 18:2, resulted in a milk fat with high levels of 18:2. These results show that there is regulation of SCD at the transcriptional level, associated with changes in enzyme activity and in milk fat composition.
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