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  • Title: Evidence of metyrapone reduction by two Mycobacterium strains shown by 1H NMR.
    Author: Combourieu B, Besse P, Sancelme M, Maser E, Delort AM.
    Journal: Biodegradation; 2004 Apr; 15(2):125-32. PubMed ID: 15068373.
    Abstract:
    In situ 1H NMR monitoring of metyrapone incubations with resting-cells of two strains of Mycobacterium, Mycobacterium aurum MO1 and Mycobacterium sp. RP1, showed the biotransformation of this compound, and more precisely the carbonyl-reduction of metyrapone into the corresponding alcohol, metyrapol. This reduction produced both enantiomers. The use of inhibitors allowed us to show the multiple enzymatic activities involved in this biotransformation including carbonyl reductase (EC 1.1.1.1.84) from the short-chain dehydrogenase superfamily and aldehyde reductase (EC 1.1.1.2) from the aldo-keto reductase superfamily.
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